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Prostate cancer (PC) is the second most frequently diagnosed neoplasm in men after lung cancer. The growing complexity of managing this pathology highlights the need to develop current clinical practice guidelines to provide a knowledge base that allows for a comprehensive approach to the patient based on the best available scientific evidence. The Clinical Practice Guideline for the management of ADVANCED PROSTATE CANCER analyzes the diagnosis and multidisciplinary treatment of advanced prostate cancer in its different stages, considering the different prognostic factors and the current stage of research in this area. . Likewise, it highlights the value and use of diagnostic imaging and genetic tests when it comes to maximizing therapeutic results, avoiding treatments and side effects.